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( [Google Scholar] 20.Chaumont M, Pourcelet A, van Nuffelen M, Racape J, Leeman M, Hougardy JM

A clinical review published in 2025 proposed that GLP-1 agonist modulation via increased serotonergic activity at the 5-HT2C receptor may result in diminished sexual desire

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You should consider speaking to your GP if you notice: Sudden or rapid hair loss over a short period Patchy hair loss or bald spots appearing on the scalp, beard, or eyebrows Diffuse thinning across the whole scalp, particularly if accompanied by fatigue, weight changes, or feeling cold which may suggest a thyroid problem Scalp symptoms such as redness, scaling, itching, pain, burning, or scarring, which may indicate an inflammatory or scarring alopecia requiring prompt assessment Hair loss alongside other symptoms such as irregular periods, acne, or unexplained weight gain (which may suggest PCOS) Hair breakage with scaling in a child, which may suggest tinea capitis and warrants prompt GP review Recent changes to medication , including starting a new statin or other lipid-lowering drug Your GP will take a thorough history and is likely to arrange blood tests to investigate potential causes

and 4) highlights their potential as locations for the rational design of novel allosteric modulators with the capacity to fine-tune GLP-1R responses