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The exact dose-response relationship in humans remains an area of active research

New Hampshire Medicaid removed coverage effective January 1, 2026, citing these medications as a significant cost driver. 12,13 Pennsylvania Medicaid removed coverage effective January 1, 2026

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Gastrointestinal adverse effects remain the most common side effects, and longer-term cardiovascular and safety data are still being collected

Severe abdominal pain, particularly if it spreads to the back, may require medical assessment

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