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If you look across the randomized trials, the adverse event rates to me are fairly alarming

Disparate hydration of adipose and lean tissue require a new model for body water distribution in man

All experiments were performed at least three times

In perfused mouse islets, GIP significantly enhances amino-acid induced glucagon secretion, and glucagon secretion after a mixed meal test is significantly impaired in -cell-specific GIPR KO mice, indicating a significant role of GIP in the regulation of amino acid-stimulated glucagon secretion [95]

Dosing - A Significant Unknown In published research showing effects, oral berberine doses typically ranged from 900-1500mg daily , often divided into multiple doses taken with meals

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