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"Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin"

Moore, Edie, Abram

It has been demonstrated utilizing genetically engineered mouse models that a high-fat meal induces hyperglycemia and hyperinsulinemia, like human T2D

Nat Med (2020) 26(2):2528

Complete tablet erosion occurred in the stomach

FIGURE 6 Plasma insulin levels sampled from the tail tended to rise from baseline about 60 min after application of semaglutide either i.v
