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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Matthews VB, et al

In the SURPASS-2 trial, which directly compared tirzepatide to semaglutide 1 mg for type 2 diabetes, nausea rates were 17-22% for tirzepatide across all three dose levels (5 mg, 10 mg, and 15 mg) versus 18% for semaglutide 1 mg

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with one of the randomized, controlled trials contributing to its FDA approval demonstrating up to 8.2% weight loss

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