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This led to the approval of the first GLP-1RA for the treatment of obesity in 2014

Half-Life, Accumulation, and Steady-State Concentration Semaglutide's 7-day half-life means that after one week, 50% of the previous dose remains in circulation

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In 354 geriatric subjects treated with ZOLOFT in MDD placebo-controlled trials, the overall profile of adverse reactions was generally similar to that shown in Table 3 [See Adverse Reactions (6.1)], except for tinnitus, arthralgia with an incidence of at least 2% and at a rate greater than placebo in geriatric patients