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Previous concerns have been raised about the potential for GLP1 agonists to cause pancreatitis (Garber et al., 2009), although this has not been confirmed in recent analyses (Storgaard et al., 2017)

A phase I/II trial of dapagliflozin in 38 lupus patients (including with and without lupus nephritis) showed an acceptable safety profile, with no increase in disease activity or proteinuria over the 6 months of the study

Those experiences can be genuine, yet a review still cannot tell you whether the patch caused the change or whether the person quietly changed their habits at the same time

2 Methods An umbrella review is used to synthesize and evaluate evidence from existing systematic reviews and meta-analyses, providing a comprehensive and holistic understanding of an issue and the highest level of evidence ( 2.1 Search strategy References for this review were identified by searching PubMed, Embase, the Cochrane Library, Web of Science, and Scopus for related studies from the inception to September 30, 2025

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