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The implications are significant because it contributes new evidence on how genetic variants can determine the effects of the same drug, making them more effective in some people than others, and whether or not they may be associated with adverse effects

When treating millions of people with medications like semaglutide, even relatively rare side effects will occur in a largenumber of people Starting low and going slow is important to minimize side effects. Susan Yanovski, MD, National Institute of Diabetes and Digestive and Kidney Diseases Common Side Effects and What Helps When To Call a Doctor

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Baseline estimated renal function was normal (eGFR 90 mL/min/1.73m 2 ) in 63.1%, mildly impaired (eGFR 60 to 90 mL/min/1.73m 2 ) in 34.3%, and moderately impaired (eGFR 30 to 60 mL/min/1.73m 2 ) in 2.5% of the patients