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As of January 6, 2025 here is a list of approved and pending new GLP-1 agonists class of medications that can help manage Type 2 diabetes and obesity: Ozempic (semaglutide) Approved - A weekly injectable GLP-1 receptor agonist that helps regulate blood sugar and suppress appetite, promoting weight loss in addition to managing type 2 diabetes

doi: 10.1210/en.2011-1070

Marx, N., Husain, M., Lehrke, M., Verma, S., & Sattar, N

A second mechanism of PKA-independent incretin potentiation of glucose-stimulated insulin secretion (GSIS) involves cAMP-regulated guanine nucleotide exchange factor (cAMP-GEF) EPAC2

Pharm Res 41 , 19912014 (2024)

Just how devastating this can be is captured by the experience of Pamela Torres, a former American track star who used to run a seven minute mile until she suffered a knee injury at college following which she rapidly gained weight