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Los agonistas de los receptores GLP-1 y GIP son tratamientos innovadores desarrollados inicialmente para la diabetes, pero que ahora se utilizan para tratar la obesidad

Abstract The development oftirzepatide, a first in class dual glucose dependent insulinotropic polypeptide andglucagon like peptide 1 receptor agonist, represents a potentially transformative advance in the management oftype 2 diabetesandobesity

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Cryo-EM analysis of a complex involving an exendin-4 analogue, the GLP-1R and Gs protein revealed two receptor conformers with distinct modes of peptide-receptor engagement