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The overproduction is supported by the activation of complex I in the colon tissue, which is a common mechanism in the control of ATP overproduction upon fuel over-loading in mitochondria 26,27

Kenneth Cusi, MD, FACP, FACE Healio | Endocrine Today Editorial Board Member Professor of Medicine Division of Endocrinology, Diabetes and Metabolism University of Florida Disclosures: Cusi reports receiving research support towards his university from Boehringer Ingelheim, Echosens, Inventiva, LabCorp and Perspectum

Clinical trials and real-world data both contribute to our understanding of this topic