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However, therapeutic effects begin to diminish sooner, with blood glucose levels typically rising within 12 weeks of discontinuation

Original Research 02 September 2025 Counterregulatory response to hypoglycemia during a hypoglycemic clamp in people with type 2 diabetes treated with tirzepatide Thomas R

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-10.9% lean body mass over 72 weeks) per the SURMOUNT-1 body-composition substudy [12]
Additionally, GLP-1 RAs can promote skin healing by reducing matrix metalloproteinases. Limitations of the study included the retrospective design, heterogeneity of concomitant HS treatments and the absence of detailed biological or glycaemic control data

GLP-1 medications have renewed focus on the science behind medical weight loss, but experts say medication alone is not enough for lasting change
