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Both Semaglutide and Tirzepatide are injectable medications used primarily to manage type 2 diabetes and assist with weight loss treatment

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Seek immediate medical attention for the following warning signs: Severe abdominal pain , particularly if persistent or radiating to the back, which may indicate pancreatitis (a rare but serious adverse effect) Persistent vomiting that prevents adequate fluid intake Signs of dehydration including decreased urination, dark urine, dizziness, dry mouth, or confusion Hypoglycemia symptoms such as shakiness, sweating, rapid heartbeat, hunger, confusion, or irritability (especially in patients taking insulin or sulfonylureas) Symptoms of gallbladder disease such as right upper abdominal pain, fever, or jaundice (yellowing of skin or eyes) Severe constipation or inability to pass stool or gas, accompanied by abdominal distention Signs of allergic reaction including rash, swelling of face/tongue/throat, or difficulty breathing (call 911) Patients with type 2 diabetes should monitor blood glucose levels more frequently during periods of significant nausea or vomiting, as reduced food intake can affect glycemic control

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Lei Qian, Vice President of Clinical Development at Innovent , stated, "Different dosage regimens of mazdutide are suitable for different groups of people with obesity

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That flexibility makes it a strong choice for the standard titration schedule

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The SURPASS program, the series of phase 3 trials that led to tirzepatide approval, enrolled thousands of participants across multiple studies

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