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Experimental studies to elucidate the beneficial effects of GLP-1 RA have mainly implicated the induction of natriuresis and the inhibition of oxidative stress, inflammation, and fibrosis [39,40,41]

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Moreover, the study interventions were implemented for a short duration

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- Safety was consistent with other GLP-1s: mainly mild-to-moderate GI events, with a slightly higher discontinuation rate during dose titration

The secondary patents, e.g., in the US, are not set to expire until 2033, thus providing Novo Nordisk with prolonged market exclusivity and delaying the launch of generics in other territories