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Genetic variation in the GLP1R gene (rs6923761) and related metabolic pathways may influence how your body responds to dosing adjustments

While no causal link between semaglutide and suicidal ideation has been established, if youre having suicidal thoughts, you should seek help right away

Sisley and colleagues used mouse genetics to inactivate the Glp1r in the mouse brain, demonstrating that the acute anorectic and chronic weight lossinducing pharmacological actions of GLP-1RA required GLP-1R expression in the central nervous system (10)

For individuals considering berberine supplementation, oral formulations represent the evidence-based choice, albeit with important caveats