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These effects are mediated through GLP-1 receptors (GLP-1R), which are widely distributed throughout the body, including the pancreas, liver, skeletal muscle, gastrointestinal tract, cardiovascular system, and central nervous system

Clinical trials demonstrate approximately 15% body weight reduction with semaglutide 2.4 mg weekly

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however, evidence regarding their effectiveness in managing WL and preventing WR post-bariatric surgery remains limited
