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Moreover, it has been shown that a GLP-1R agonist attenuated ER stress by downregulating ATF-4, a biomarker of ER stress, and inhibited apoptosis in INS-1 -cells, which could improve cell survival 43

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The funnel plot for TNF- changes in the GLP-1 RA add-on therapy subgroup is also presented ( Supplementary Figure S5 )

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