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Following PSM, a total of 7392 individuals were selected, corresponding to 1848 patients for each of the four study groups (GLP-1 receptor agonists, SGLT-2 inhibitors, insulin and miscellany groups) (Table 1)

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In the treatment-policy estimand analysis, at week 26 oral semaglutide (1.2% mean A1C reduction from baseline) met criteria for noninferiority when compared with liraglutide (1.1% mean A1C reduction from baseline) and met criteria for superiority when compared with placebo (0.2% mean A1C reduction from baseline