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Both were first approved for treating type 2 diabetes

Steady improvements over time

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In animal experiments on such drugs, studies on rodents have found that the GLP-1RAs may promote the development of medullary thyroid carcinoma, but this effect has not been observed in non-human primates [23]

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Therefore, we conclude our crystal structure represents a physiologically relevant snapshot of GLP-1R in an inactive peptide-free state