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The FDA says it has received reports some compounders may be using salt forms of semaglutide, including semaglutide sodium and semaglutide acetate, which are different from the active ingredient used in Ozempic and Wegovy

Moreover, both medications have been associated with improvements in cardiometabolic risk factors, such as blood pressure, cholesterol levels, and glycemic control, which are crucial for overall health and well-being

Ban on Ozempic replicas The Federal Government announced that from 1 October 2024, compounding pharmacies will be banned from producing replicas of Ozempic and Mounjaro citing a clear risk to human health from their large-scale manufacture

Some clinicians prefer a longer washout (up to 30 days) to reduce overlap

It is noteworthy that although GLP-1 and insulin combination therapy may provide convenience in practice, combination therapy comes at the cost of diminished dosing flexibility of both drugs, raising concerns about whether the specific combination therapy actually achieves better therapeutic efficacy than two drugs that are titrated separately
