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At about the same time, two synthetic derivatives of galegine, metformin and phenformin, were first synthesised and tested, although they were not introduced to clinical use until the 1950s [3]

doi: 10.5114/pg.2020.95554 Damianos JA, Fredrick TW, Jin MF, Ospina-Velasquez L, Wang XJ

Moderation is the minimum recommendation, and many users choose to reduce or eliminate alcohol during treatment

One of the drugs, Zepbound, mimics GLP-1 as well as a hormone called a glucose-dependent insulinotropic polypeptide (GIP), believed to promote the effects of GLP-1

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This makes it impractical for routine clinical use, necessitating the development of modified GLP-1 receptor agonists like semaglutide