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The Phase 2 data showing 24.2% body weight loss in 48 weeks through a novel triple-agonist mechanism is unprecedented

Cagrilintide is an amylin analog it works through a completely different receptor system than GLP-1

[DOI] [PubMed] [Google Scholar] 102.Stevenson J.R., Francomacaro L.M., Bohidar A.E., Young K.A., Pesarchick B.F., Buirkle J.M., McMahon E.K., OBryan C.M

The EXSCEL (NCT01144338), HARMONY (NCT02465515), REWIND ( NCT01394952), and AMPLITUDE-O (NCT03496298) trials all demonstrated cardioprotection or near misses for exenatide, albiglutide, dulaglutide and efpeglenatide, respectively

OASIS-4 smaller, mostly women and white participants Administration: orforglipron without restrictions

Effects of liraglutide or lifestyle interventions combined with other antidiabetic drugs on abdominal fat distribution in people with obesity and type 2 diabetes mellitus evaluated by the energy spectrum ct: A prospective randomized controlled study