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At week 13, significant reductions versus placebo were observed in glycated hemoglobin (HbA1c: 0.87%), body weight (2.54%), systolic blood pressure (SBP: 3.84 mmHg), pulse pressure (3.81 mmHg), high-sensitivity C-reactive protein (hsCRP: 18.08%), and lipid parameters including total cholesterol (7.00%), nonHDL-C (8.02%), and triglycerides (8.15%)

Crucially, the inflammatory pathways that semaglutide reversed overlapped with those seen in human Alzheimer's disease, suggesting the findings may matter well beyond this mouse model

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This study included 41 participants (RYGB: n=21, OAGB: n=20) from the randomized RYSA trial with similar amounts of bypassed intestine between the procedures