is it ok to switch from tirzepatide to semaglutide A Comprehensive Guide for Smooth Transition Early Dose Escalation of Tirzepatide

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However, DPP-4 inhibitors (such as sitagliptin or linagliptin) should be discontinued when initiating semaglutide, as both drug classes work through incretin pathways, and combined use offers no additional glycemic benefit while potentially increasing adverse effects

Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, Changshu 215500, Jiangsu Province, China

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Although this has been found to be the case, it was also found that other preprocedural GI effects were observed with a higher incidence in GLP-1 RA users such as reduced gastric acidity, nausea, vomiting, dyspepsia, and abdominal distension (OR 15.1