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References 10

Most of these side effects are caused by delayed gastric emptying that results in feelings of fullness that deter appetite and cause weight loss

Vitamin B-12 or glycine are added for additional support

doi: 10.2337/db17-0316

The characteristics of heart rate increase appear to be: Dose-dependent : Higher doses generally produce greater increases Agent-specific : Some GLP-1 receptor agonists may have more pronounced effects than others Time-dependent : Heart rate changes typically occur early in treatment and may stabilise over time Clinically modest : The absolute increase is generally small and within normal physiological variation Proposed mechanisms for heart rate elevation include modulation of autonomic nervous system activity, with potential reduction in parasympathetic (vagal) tone or increase in sympathetic activity
