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In fact, it is reported (Underwood et al., 2010) that exendin-4 (939) binds strongly (EC 50 5 pM, IC 50 0.76 nM) to wild-type GLP-1R than the native GLP-1 (EC 50 11 pM, IC 50 1 nM)
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Clinical Pharmacokinetics of Semaglutide: A Systematic Review
If diarrhea significantly impacts your quality of life or prevents you from taking your medication as prescribed, your provider may recommend dose adjustment, a temporary pause, or switching to a different formulation
doi: 10.3389/fphar.2018.00557
