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Description
Both tirzepatide and retatrutide produce gastrointestinal side effects as their primary adverse reactions, but the frequency, severity, and specific patterns differ between the two compounds
PMID 41500720

Its a triple-action medication that mimics the effects of three hormones: GLP-1, GIP, and glucagon

228,229 The opening of these channels is controlled by the intracellular ATP/ADP ratio

Use of GLP-1RAs for other conditions One thing is for sure, despite this class of medications being primarily sold for diabetes and now for weight loss, they are being investigated for much more beyond their potential use for MCAS

Efficient (18)F-labeling of synthetic exendin-4 analogues for imaging beta cells
