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Locally, IGF-1 is synthesized by various brain cells in the CNS, with peak levels during the perinatal stage and widespread distribution throughout different brain regions, including the cerebral cortex, hippocampus, cerebellum, brain stem, hypothalamus, and spinal cord

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[24] Contraindications [edit] Dulaglutide should not be taken for patients with a personal family history of medullary thyroid carcinoma or in patients with multiple endocrine neoplasia syndrome type 2

Bright red blood typically indicates bleeding near the anus, while dark or black stools may indicate bleeding from higher up in the gastrointestinal tract