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Destruction of DNA-binding proteins by programmable oligonucleotide PROTAC (OPROTAC): effective targeting of LEF1 and ERG

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Unknown long-term safety: Long-term effects of exogenous glutathione administration are not well-studied Injection technique: Must be administered by or under the direction of a qualified provider Common Side Effects Injection site reactions: pain, redness, swelling Mild nausea Lightheadedness Transient sulfur-like odor or taste Headache Temporary changes in skin pigmentation Seek Immediate Medical Attention For Signs of severe allergic reaction: rash, itching, swelling of face/tongue/throat, severe dizziness, trouble breathing Widespread skin rash or peeling skin Chest pain or difficulty breathing Signs of liver problems: yellowing of skin or eyes, dark urine, severe fatigue Use in Pregnancy and Breastfeeding Safety has not been established

Electrophysiological recordings revealed that GLP-1R activation increased excitability of medium spiny neurons in the NAc, particularly D1-expressing subpopulations [27]