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Preclinical studies in animal models have demonstrated that survodutide effectively activates both GLP-1R and GCGR, resulting in reduced body weight, slower gastric emptying, decreased energy intake, increased energy expenditure, and improved glucose tolerance [86]

Some patients experience more pronounced nausea, appetite suppression that feels excessive, or GI issues on tirzepatide that do not resolve over time

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Nephron 145, 1-13 (2021)
