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Therapy Initiation: Start lisinopril 10mg daily

Most reproductive health specialists recommend stopping semaglutide 23 months before you begin trying to conceive, though some consider a shorter window acceptable given semaglutide's rapid clearance (7-day half-life)

Weight can return if the medication is stopped without a maintenance plan in place

Clinical trials evaluating the efficacy of semaglutide in UC have provided compelling evidence supporting its role as a promising therapeutic option for patients with moderate-to-severe disease

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Weight loss during this period is typically 2 to 4 pounds, primarily from reduced caloric intake and initial fluid shifts