2.4 semaglutide Ozempic® (semaglutide) GLP-1 RA for Type 2 Diabetes Semaglutide- for weight loss in

Disclosures: Sadiya S

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[DOI] [PubMed] [Google Scholar] 49.Steinert RE, Poller B, Castelli MC, Drewe J, Beglinger C

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GLP-1 Receptor Activation: Suppresses appetite through hypothalamic pathways Slows gastric emptying Enhances insulin secretion GIP Receptor Activation: Amplifies GLP-1 satiety effects Improves insulin sensitivity May directly affect fat cell metabolism Glucagon Receptor Activation: Increases energy expenditure (metabolic rate) Promotes fat breakdown (lipolysis) May prevent metabolic adaptation The Advantage: Single molecule means simpler manufacturing, potentially easier regulatory approval, and all three pathways activated with every dose

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