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Additionally, Mounjaros unique mechanism may help reduce food cravings, improve insulin sensitivity, and support better cholesterol and inflammation profilesthough research is ongoing in these areas

GLP-1 receptor agonists and SGLT2 inhibitors in type 2 diabetes: Pleiotropic cardiometabolic effects and add-on value of a combined therapy

The results of a transcriptomic analysis obtained from a mouse model also revealed that the stimulation of GLP-1 receptor by high doses of exendin-4 upregulates IGF-1R typically in pancreatic islets, thus reinforcing the concept that activating the IGF-1R/IRS-2/Akt pathway mediates the prevention of -cell loss under the control of incretins (40)

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Discussion Overall, participants with obesity and/or T2D described a positive impact of GLP-1 receptor agonists on their mental health, especially perception of improved control of eating behaviours