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Priority design elements: (i) Statistical Power and Follow-up

Pharmacokinetics Eight-weeks-old male C57BL/6 mice ( n =3 per group) were injected with a single subcutaneous dose of P5 or Ex4 (100 g kg 1 ), and blood was collected 1, 2, 4, 8 and 24 h later

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Antibody treatment and body composition For the initial mouse study, antibody treatments were given subcutaneously on days 0, 4, 7, 14, and 21