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When there is a concern for retained gastric contents on the day of the procedure, point-of-care gastric ultrasound can be used to assess volume of gastric contents and pulmonary aspiration risk

Semaglutide GLP-1 injections help to control blood sugar levels by stimulating insulin production and reducing the production of glucagon, a hormone that raises blood sugar levels

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In a recent Mayo Clinic study, postmenopausal women who were overweight or had obesity and combined semaglutide and HRT experienced about 30% more significant weight loss than those using semaglutide alone

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Other companies, including Terns Pharmaceuticals (TERN-601), Structure Therapeutics (GSBR-1290), and Viking Therapeutics, have oral GLP-1 programs at earlier stages of development, but none has reached Phase 3 or generated the depth of clinical data available for orforglipron