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A regional health system database comprising over 12,000 colonoscopies further showed that a 7-day semaglutide interruption failed to restore bowel preparation to baseline levels (adjusted OR 1.6) and was accompanied by modest, yet measurable, elevations in HbA1c and early weight regain [41]

Black A vitamin that contains iron or medication that contains bismuth subsalicylate, such as Pepto-Bismol, can cause this, but black stools can also signal a more serious problem

N Engl J Med 2022;387:20516.ArticlePubMed 10

This balance supports a steady energy level

For tirzepatide (Mounjaro), the SmPC advises that it can reduce the exposure to oral contraceptives, so additional barrier contraception is recommended for 4 weeks after initiation and after each dose escalation

Hormonal fluctuations: Rapid changes in body composition can temporarily disrupt thyroid function and estrogen balance, further contributing to hair shedding