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Investigating incretin-based therapies as a novel treatment for depression in type 2 diabetes: Findings from the South London Diabetes (SOUL-D) Study

Its main modification is a C16 palmitoyl moiety covalently attached to the lysine at position 20 through a -glutamic acid chemical spacer

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And while the drugs safety profile appears to be in line with approved GLP-1 drugs, at least some people discontinued taking retatrutide due to the drugs adverse effects