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Description
REDEFINE-1 showed that adding amylin to a GLP-1 backbone improves results

At 75, things that use to work just didn't work anymore
Common sites include the abdomen, the thighs, and the upper arms

[DOI] [PMC free article] [PubMed] 4.E

Another ongoing trial will also investigate the effects of tirzepatide on CKD in patients with or without T2D, with a primary outcome of change in kidney oxygenation (TREASURE-CKD, NCT05536804) [71]

While GIPR agonism appears to enhance the efficacy of GLP-1R agonism for glucose control and weight loss, its impact on the antiinflammatory actions of GLP-1R agonism is less clear
