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Background Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have emerged as breakthrough weight loss agents

2 GLP-1R monotherapy (e.g., semaglutide) is highly effective, but dual GLP-1R/GIPR agonists (e.g.,

However, the role of endogenous GLP-1 in the attenuation of reward-oriented behavior, and the essential domains of the mesolimbic system mediating these beneficial effects, are largely unknown

Semaglutide belongs to a class of medications known as GLP-1 receptor agonists, which influence hormones involved in appetite regulation and metabolic signaling

Immunofluorescence, Western blot, and RT-qPCR were used in the study

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