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Whats Next: Regulatory filing for weight management: by end of 2025 Submission for type 2 diabetes: expected in 2026 Drug discovered by Chugai, licensed by Lilly in 2018 Implication: Orforglipron could become the first once-daily oral GLP-1 therapy with potent glucose-lowering and weight-loss benefits, potentially disrupting the injectable incretin market.

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There is a boxed warning for Ozempic and Trulicity, which is the most serious warning required by the FDA

Q: What if my patient is already on psychiatric meds that cause weight gain

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Balancing Efficacy and Gastrointestinal Side Effects Experts generally agree that semaglutide is a breakthrough in the management of type 2 diabetes and obesity due to its efficacy in improving glycemic control and promoting significant weight loss