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Once it reaches the bloodstream, it is directly inactivated within seconds by the enzyme dipeptidyl peptidase-4 (DPP-4), which cleaves the peptide between positions 8 and 9, converting it into the truncated form GLP-1(936) amide

This model helps patients develop lasting habits while on treatment, which supports long-term success whether medication continues or is eventually tapered

These fatty obstructions can reduce or limit absorption, and may remain for weeks or months

Cost-effectivness of GLP-1 agonist use

2014;9 doi: 10.1371/journal.pone.0096863

One GLP-1RA, liraglutide, has been approved to treat obesity, and another, semaglutide, is in clinical trials