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GLP-1 receptor agonists have been shown to reduce major adverse cardiovascular events including cardiovascular death, heart attack, and stroke in patients with type 2 diabetes

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Patients scheduled for colonoscopy or other procedures requiring sedation should follow their gastroenterologist's or anesthesiologist's instructions regarding whether to hold GLP-1 medications before the procedure, as delayed gastric emptying may affect sedation safety

There are risks to the mother and fetus associated with poorly controlled diabetes in pregnancy (see Clinical Considerations )

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Takaya K, Ariyasu H, Kanamoto N, et al