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20 Historically, most clinical trials assessing different medications for HFpEF have yielded neutral results when it comes to exerciserelated outcomes like the 6min walk distance or cardiopulmonary exercise testing

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Nissen expects tirzepatide to soon join the pure GLP-1 RAs with an FDA-approved indication for weight loss in addition to diabetes, although it may meet the same payer reluctance around reimbursement for weight loss that the pure GLP-1 RAs have

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