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Similarly, severe abdominal pain, particularly if localised to the upper abdomen and radiating to the back, requires urgent assessment to exclude pancreatitis, a rare but serious potential adverse effect of GLP-1 receptor agonists identified in the Wegovy SmPC and MHRA safety monitoring

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Constipation paradoxically affects a similar percentage of users, sometimes alternating with diarrhea as the digestive system adapts

All of the studies demonstrate that prescribing a GLP-1 receptor agonist is cost-effective 47,5254