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The increase in this strength often depends on the individuals metabolic response and overall tolerance to the drug
However, a substantial percentage of patients (between 30 and 50%) have the condition with an unknown cause, termed idiopathic gastroparesis

doi: 10.1016/j.cell.2013.11.002

According to a press release, Barkley was inspired to sign on to the position due to his personal experience with GLP-1s