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What should patients, physicians, insurers, policy makers, and researchers know about GLP-1 cost, access, and safety
They enhance insulin secretion, suppress glucagon release, slow gastric emptying, and promote satiety

The most common designs are observational studies

Limited head-to-head studies compare established glucagon-like peptide-1 receptor agonists (GLP-1 RAs), dipeptidyl peptidase-4 inhibitors (DPP-4is), and sodium-glucose co-transporter-2 inhibitors (SGLT-2is) to insulin in the management of uncontrolled type 2 diabetes mellitus (T2DM)

Two major ongoing trials are likely to change that, with potentially big implications for clinical practice.

Interestingly, glucagon-like peptide-1 receptor agonists (GLP-1RAs), used in the treatment of T2DM and obesity, are known to show pro-cognitive and neuroprotective properties, and exert modulatory effects on immune, endocrine and metabolic processes in the central nervous system
