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In animal studies, glucagon-like peptide-1 receptor agonists consistently reduce drug intake, attenuate dopamine release in reward circuits, and decrease relapse-like behavior

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While adenosine triphosphate (ATP) signaling was enhanced in cultured DRG neurons treated with exendin-4, capsaicin sensitivity and calcium influx remained unaffected, suggesting GLP-1R predominantly modulating gut motility rather than pain signaling [55]

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This may highlight a broader issue of under-testing and under-diagnosing SIBO