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95% CI 0.19, 2.7) and cyproterone acetate/ethinyl estradiol (WMD: 2.28

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The mechanism of DPP-4 inhibitors is to increase incretin levels (GLP-1 and GIP), [2] [3] [4] which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels

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doi: 10.1185/030079908X253870 6 GaspariTLiuHWelungodaIHuYWiddopREKnudsenLBet al

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Assuming a 10% incidence of the primary endpoint and a 15% relative risk reduction, the statistical power to detect a significant difference with just 277 patients would be only 11%

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Why Individual Response to GLP-1 Varies: Key Effectiveness Factors GLP-1 effectiveness depends on multiple interconnected factors: baseline metabolic health, insulin sensitivity, gastrointestinal adaptation, genetic variations in GLP-1 signaling pathways, and adherence consistency

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