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Glucagon-like peptide-1 receptor agonists and risk of bone fracture in patients with type 2 diabetes: A meta-analysis of randomised controlled trials
So a 12.5% deficit at your starting weight becomes a smaller deficit at a lower weight, even if your eating stays exactly the same

That's usually a mistake

Your appetite control system doesn't automatically stay reset

Repeated episodes of BBB disruption may contribute to long-term epileptogenesis

2006;4:e002