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IR GLP-1 RAs address IR through multiple mechanisms

To make it work, you need: High protein intake Structured resistance training A mild calorie deficit (not extreme) If calories drop too low, muscle gain becomes unlikely

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Heres how they work their magic: They curb your appetite: GLP-1s send signals to your brain that youre full, so you feel satisfied with smaller portions

73 One of the bicyclic peptides, [d-Ala 8 ]-c[Glu 18 , Lys 22 ]-c[Glu 30 , Lys 34 ]-GLP-1(736)-NH 2 ( 6 ), was found to show outstanding metabolic stability as well as higher potency compared to GLP-1 73 (Figure 2)

For example, protein recommendations during major weight reduction are based on adjusted body weight range between 1.2 and 2.0 g/kg of adjusted body weight/day [156]